| Expression pattern: |
UP |
| Associated gene: |
AKT3 |
| Associated microRNA: |
miR-610 |
| Biological function: |
Favorable prognostic biomarker in MM (high expression associated with longer PFS and OS); reported to enhance MM proliferation and metastatic potential (via miRNA sponging). |
| Molecular mechanism: |
microRNA sponging (ceRNA-like) involving miR-610 leading to AKT3 upregulation. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); metastasis (promotes) |
| Detected method: |
Q
|
| Validation methods: |
divergent primers PCR; Back-Splice Junction PCR; RT-qPCR; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Survival Analysis |
| Clinical significance: |
High circCCT3 expression is a favorable prognostic factor in MM (longer PFS and OS), independent of R-ISS stage and age; can further stratify R-ISS stage II patients; ROC analysis suggests it can distinguish MM from SMM. |
| Description: |
circCCT3 is up-regulated in CD138+ plasma cells from MM compared with SMM and shows diagnostic separation of MM vs SMM by ROC analysis. High circCCT3 expression is associated with better PFS and OS and further stratifies R-ISS stage II patients as a favorable prognostic biomarker. |
| Confidence score: |
0.6656 |