| Expression pattern: |
UP |
| Associated gene: |
SPI1, IL6, METTL3, YTHDC1 |
| Associated microRNA: |
- |
| Biological function: |
promotes cell survival, proliferation, invasion, and migration |
| Molecular mechanism: |
circSTX6 binds SPI1 and inhibits its ubiquitin-mediated degradation to stabilize SPI1; SPI1 transcriptionally upregulates IL6 activating JAK2/STAT3 signaling; METTL3-mediated m6A modification recognized by YTHDC1 increases circSTX6 stability, forming a METTL3/circSTX6/SPI1 positive feedback loop |
| Biological pathway or process: |
JAK/STAT (promotes); proliferation (promotes); invasion (promotes); migration (promotes); m6A modification (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Survival Analysis; Transfection; CCK8; EdU Staining; Transwell Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; ChIP / ChIP-seq; ELISA; Western Blot; MeRIP / MeRIP-seq; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry) |
| Clinical significance: |
high circSTX6 expression is associated with poor patient prognosis and shorter overall survival |
| Description: |
circSTX6 (hsa_circ_0007905) is up-regulated in cervical cancer and predicts worse overall survival. It promotes proliferation, invasion and migration by binding and stabilizing SPI1, which increases IL6 transcription and activates the IL6/JAK2/STAT3 pathway. METTL3-dependent m6A modification (read by YTHDC1) stabilizes circSTX6, forming a METTL3/circSTX6/SPI1 positive feedback loop. |
| Confidence score: |
0.8849 |