circRNA basic information
circBase ID: -
Name: hsa_circ_POLA2
Synonym: circ_POLA2
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0018177
MONDO name: glioblastoma
Disease details: glioblastoma / GBM
Disease DO ID:
 3068
Disease MeSH ID:
 D005909
Disease NCIt ID:
 C3058
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

GBM tissues; adjacent nontumor tissues
Cell lines:

U-138; U-235; U215
In vivo animal model:

other disease animal model
circRNA-disease information
Expression pattern:
UP
Associated gene: PTEN
Associated microRNA: -
Biological function: circ_POLA2 is upregulated in GBM and its overexpression suppresses GBM cell apoptosis; the paper also reports effects on tumor formation in nude mice.
Molecular mechanism: circ_POLA2 acts upstream of PTEN and may suppress GBM cell apoptosis by downregulating PTEN at the mRNA and protein levels, possibly at the transcriptional level.
Biological pathway or process:

apoptosis (inhibits)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Transfection; Western Blot; Annexin V/PI Flow Cytometry; In Vivo Animal Model
Clinical significance:

-
Description:

This study reports that circ_POLA2 is upregulated in human GBM tissues. Functionally, circ_POLA2 overexpression suppresses apoptosis of GBM cell lines and reduces PTEN expression at both mRNA and protein levels, suggesting a circ_POLA2/PTEN-related anti-apoptotic mechanism in GBM.
Confidence score:

0.5358
Other information
Title:

CircRNA circ_POLA2 overexpression suppresses cell apoptosis by downregulating PTEN in glioblastoma.

Journal: Anti-cancer drugs
Published: 2023
PubMed ID: 36730613
Study type:

combined biological and clinical study
Data availability: the analyzed data sets generated during the present study are available from the corresponding author upon reasonable request
Code availability: -