| Expression pattern: |
DS |
| Associated gene: |
TCF7, LEF1, Wnt11, beta-catenin |
| Associated microRNA: |
miR-103a-1-5p |
| Biological function: |
promotes proliferation, viability, migration/invasion and inhibits apoptosis in gastric cancer cells |
| Molecular mechanism: |
circMORC1 acts as a miRNA sponge for miR-103a-1-5p, affecting downstream Wnt signaling pathway-related genes/proteins (e.g., TCF7, Wnt11, beta-catenin). |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis; Luciferase Reporter Assay; RNA Pull-Down; Transfection; CCK8; EdU Staining; Colony Formation Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Western Blot |
| Clinical significance: |
circMORC1 in plasma-derived EVs was significantly different between gastric cancer patients and healthy individuals; proposed as a biomarker for GC diagnosis and prognosis. |
| Description: |
circMORC1 shows opposite expression trends in GC: decreased in plasma EVs but increased in GC cells. It promotes GC cell proliferation/viability and migration/invasion and inhibits apoptosis by sponging miR-103a-1-5p, thereby affecting Wnt/beta-catenin pathway activity and related targets (e.g., TCF7, Wnt11). It is proposed as a plasma EV biomarker for GC diagnosis/prognosis. |
| Confidence score: |
0.7759 |