| Expression pattern: |
DN |
| Associated gene: |
RASSF6 |
| Associated microRNA: |
miR-524 |
| Biological function: |
Overexpression of circITCH suppresses OS cell viability, migration and invasion, promotes apoptosis, reduces doxorubicin resistance, and constrains tumor growth in vivo. |
| Molecular mechanism: |
circITCH acts as a ceRNA sponge for miR-524 to up-regulate RASSF6, thereby repressing OS progression and reducing doxorubicin resistance. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); drug resistance (inhibits); chemoresistance (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; In Vivo Animal Model |
| Clinical significance: |
circITCH was down-regulated in OS tissue samples and was lower in DXR-resistant patients than DXR-sensitive cases, suggesting relevance to OS development and doxorubicin resistance. |
| Description: |
circITCH is down-regulated in osteosarcoma tissues, OS cell lines, and doxorubicin-resistant samples/cells. Its overexpression suppresses OS malignant phenotypes and doxorubicin resistance by sponging miR-524 to up-regulate RASSF6, and it also reduces xenograft tumor growth in vivo. |
| Confidence score: |
0.7795 |