| Expression pattern: |
UP |
| Associated gene: |
NKX2-2, NEK2, PRAME, RAD54L |
| Associated microRNA: |
miR-661, miR-143-5p |
| Biological function: |
May contribute to breast cancer development and be associated with response to neoadjuvant therapy, via ceRNA regulation affecting apoptosis, cell cycle progression, and senescence-related programs. |
| Molecular mechanism: |
ceRNA mechanism: circRNA_31003 may sponge miRNAs (miR-661; miR-143-5p) to regulate TFs (NKX2-2; PRAME) and downstream mRNAs (NEK2; RAD54L). |
| Biological pathway or process: |
ceRNA regulation (other); apoptosis (other); cell cycle (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis |
| Clinical significance: |
Candidate biomarker for response to neoadjuvant therapy (NAT) in breast cancer. |
| Description: |
circRNA_31003 is upregulated in pre-therapy breast cancer tumor tissues versus adjacent normal tissues and decreases after NAT. It is proposed to act in a ceRNA network by sponging miR-661 and miR-143-5p to modulate NKX2-2/NEK2 and PRAME/RAD54L axes, potentially contributing to tumorigenesis and NAT response. |
| Confidence score: |
0.4032 |