| Expression pattern: |
UP |
| Associated gene: |
RRM2 |
| Associated microRNA: |
miR-593-5p |
| Biological function: |
Promotes proliferation, migration and aerobic glycolysis and inhibits apoptosis in gastric cancer cells under CoCl2-induced hypoxia; contributes to tumor growth in vivo. |
| Molecular mechanism: |
Acts as a ceRNA by binding miR-593-5p to regulate RRM2, affecting glycolysis-related proteins (e.g., HIF-1alpha, HK2, ENO1, LDHA, GLUT1, PKM2) and CoCl2-induced malignant phenotypes. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); apoptosis (inhibits); cell cycle (other); glycolysis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
Bioinformatics Analysis; RNA-seq; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
Potential independent prognostic biomarker and therapeutic target for gastric cancer. |
| Description: |
circ_0043256 is up-regulated in gastric cancer tissues and GC cell lines. Its knockdown suppresses CoCl2-induced proliferation, migration/invasion, and aerobic glycolysis while promoting apoptosis and G2/M arrest. Mechanistically, circ_0043256 binds miR-593-5p to regulate the miR-593-5p/RRM2 axis and downstream glycolysis-related proteins, and its silencing inhibits tumor growth in xenograft models. |
| Confidence score: |
0.7375 |