| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
miR‐129‐5p, miR‐136‐5p |
| Biological function: |
inhibits cell proliferation; promotes apoptosis |
| Molecular mechanism: |
Proposed miRNA sponge mechanism (miR‐129‐5p, miR‐136‐5p) based on TSCD database; not experimentally validated in this study. |
| Biological pathway or process: |
proliferation (inhibits); apoptosis (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Clinical Sample Validation; Cohort Study; Survival Analysis; ROC Analysis; Transfection; CCK8; Annexin V/PI Flow Cytometry |
| Clinical significance: |
Downregulated in breast cancer tumour tissues; good value to distinguish tumour from adjacent tissue (ROC AUC 0.720); high expression associated with smaller tumour size, reduced T stage, lower TNM stage; independent predictor of better overall survival. |
| Description: |
circ‐VRK1 is down-regulated in breast cancer tumor tissues and lower in several breast cancer cell lines. Functionally, circ‐VRK1 suppresses proliferation and promotes apoptosis in MDA‐MB‐231 cells, and higher circ‐VRK1 expression is associated with earlier stage disease and better overall survival. |
| Confidence score: |
0.7211 |