circRNA basic information
circBase ID: hsa_circ_0001508
Name: -
Synonym: circ_0001508
Host Gene: -
Genomic location(hg19): chr5:80071512-80088663:+
Genomic location(hg38): chr5:80775693-80792844:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

BC tissues; adjacent BC normal tissues
Cell lines:

HCC1806; HCC1937; CAL-51; MCF10A
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: HMGB1, VGLL3
Associated microRNA: miR-505-3p
Biological function: Promotes proliferation, migration and invasion; inhibits apoptosis in breast cancer cells.
Molecular mechanism: Putative ceRNA/sponging regulation: hsa_circ_0001508 may inhibit miR-505-3p, thereby increasing HMGB1 and VGLL3 expression.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Transfection; MTT; Transwell Assay; Wound Healing Assay; Annexin V/PI Flow Cytometry; Western Blot; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0001508 is up-regulated in breast cancer tissues and highly expressed in HCC1937 cells. Silencing hsa_circ_0001508 suppresses proliferation, migration and invasion and increases apoptosis, and is associated with increased miR-505-3p and decreased HMGB1/VGLL3 expression, supporting a putative hsa_circ_0001508-miR-505-3p-HMGB1/VGLL3 regulatory axis.
Confidence score:

0.5089
Other information
Title:

hsa_circ_0001508 as a new gene that may promote breast cancer progression via the miR‑505‑3p/HMGB1, VGLL3 axis.

Journal: Molecular and clinical oncology
Published: 2025
PubMed ID: 39720459
Study type:

combined biological and clinical study
Data availability: GSE182471; https://circinteractome.nia.nih.gov/api/v2/circsearch?circular_rna_query=hsa_circ_0001508+&gene_symbol_query=&submit=circRNA+Search
Code availability: -