| Expression pattern: |
UP |
| Associated gene: |
YY1, ULK1 |
| Associated microRNA: |
miR-670-3p |
| Biological function: |
promotes proliferation, invasion, and autophagy in EOC; promotes xenograft tumor growth |
| Molecular mechanism: |
sponges miR-670-3p to enhance YY1 expression; directly interacts with ULK1 to regulate autophagy |
| Biological pathway or process: |
autophagy (promotes); proliferation (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RT-qPCR; Clinical Sample Validation; FISH / smFISH; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); Western Blot; Transfection; EdU Staining; Transwell Assay; In Vivo Animal Model; IHC (Immunohistochemistry) |
| Clinical significance: |
suggested as a potential biomarker and potential target for treating EOC |
| Description: |
circFAM188A is up-regulated in epithelial ovarian cancer tissues and promotes EOC cell proliferation and invasion. It enhances autophagy mainly by sponging miR-670-3p to upregulate YY1 and by directly interacting with ULK1, leading to increased autophagic flux and xenograft tumor growth. |
| Confidence score: |
0.8455 |