circRNA basic information
circBase ID: hsa_circ_0001189
Name: -
Synonym: hsa-circ-0001189
Host Gene: -
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0019939
MONDO name: early-onset schizophrenia
Disease details: early-onset schizophrenia / EOS
Disease DO ID:
 -
Disease MeSH ID:
 -
Disease NCIt ID:
 -
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

blood
Cell lines:

HEK293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UN
Associated gene: -
Associated microRNA: hsa-miR-708-3p
Biological function: Binds hsa-miR-708-3p, but knockdown did not alter hsa-miR-708-3p, JARID2, or LNPEP expression in transfection assays.
Molecular mechanism: Stable binding to hsa-miR-708-3p; regulatory effect not supported by knockdown expression changes
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Luciferase Reporter Assay; Transfection; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa-circ-0001189 can bind hsa-miR-708-3p (luciferase), but its knockdown did not change hsa-miR-708-3p, JARID2, or LNPEP levels, suggesting it is not a functional ceRNA regulator in the EOS axis established here.
Confidence score:

0.7399
Other information
Title:

The neurodevelopmental regulatory role and clinical value of hsa-circ-CORO1C-hsa-miR-708-3p-JARID2 + LNPEP axis in early-onset schizophrenia.

Journal: Schizophrenia (Heidelberg, Germany)
Published: 2024
PubMed ID: 39702523
Study type:

combined biological and clinical study
Data availability: GSE280723; GSE280722
Code availability: -