| Expression pattern: |
DN |
| Associated gene: |
JARID2, LNPEP |
| Associated microRNA: |
hsa-miR-708-3p |
| Biological function: |
Acts as a sponge for hsa-miR-708-3p and alleviates its suppressive effects on JARID2 and LNPEP; contributes to neurodevelopmental abnormalities and provides diagnostic value in EOS. |
| Molecular mechanism: |
ceRNA mechanism (miRNA sponge) regulating JARID2 and LNPEP via hsa-miR-708-3p |
| Biological pathway or process: |
ceRNA regulation (promotes); neuronal differentiation (promotes); migration (not specified) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; RNase R Treatment; Luciferase Reporter Assay; Transfection; Clinical Sample Validation; ROC Analysis; In Vivo Animal Model |
| Clinical significance: |
Diagnostic biomarker potential; ROC AUC=0.6563 for hsa-circ-CORO1C; combined axis AUC=0.8037. |
| Description: |
In EOS, hsa-circ-CORO1C is downregulated and functions as a ceRNA by sponging hsa-miR-708-3p, thereby relieving repression of JARID2 and LNPEP. This multi-molecular axis shows diagnostic value (ROC) and is linked to neurodevelopment-related effects through downstream targets. |
| Confidence score: |
0.797 |