| Expression pattern: |
UP |
| Associated gene: |
IGF2BP1, PTBP1 |
| Associated microRNA: |
miR-92a-1-5p |
| Biological function: |
Promotes CRC cell proliferation, migration, invasion and metastasis; promotes EMT; modulates tumor-stroma microenvironment (CAF activation, M2 macrophage polarization); reduces sensitivity to oxaliplatin. |
| Molecular mechanism: |
Acts as a ceRNA sponging miR-92a-1-5p to upregulate IGF2BP1; directly binds PTBP1 and inhibits ubiquitination/proteasome-dependent degradation of PTBP1, enhancing PTBP1-mediated IGF2BP1 mRNA stabilization. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); EMT (promotes); ceRNA regulation (promotes); immune regulation (promotes); drug resistance (promotes); ubiquitination (inhibits) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; RNase R Treatment; Actinomycin D / DRB Stability Assay; Sanger Sequencing; Back-Splice Junction PCR / divergent primers PCR; FISH / smFISH; Clinical Sample Validation; Bioinformatics Analysis; RNA-seq; Luciferase Reporter Assay; RNA Pull-Down; RIP (RNA Immunoprecipitation); Transfection; Western Blot; CCK8; EdU Staining; Transwell Assay; Wound Healing Assay; Colony Formation Assay; IF (Immunofluorescence); Co-IP; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry) |
| Clinical significance: |
Higher levels in serum exosomes correlate with advanced TNM stages; high circSCP2 expression is associated with poor prognosis; exosomal circSCP2 is a promising circulating biomarker for CRC prognosis. |
| Description: |
circSCP2 (hsa_circ_0006906) is up-regulated in CRC tissues and circulating/serum exosomes and promotes proliferation, EMT, invasion and metastasis. It acts as a miR-92a-1-5p sponge to increase IGF2BP1 and also binds PTBP1 to inhibit PTBP1 ubiquitination, thereby stabilizing PTBP1 and enhancing IGF2BP1 mRNA stability. Exosomal circSCP2 additionally influences the tumor microenvironment (e.g., CAF activation and M2 macrophage polarization) and is proposed as a prognostic circulating biomarker. |
| Confidence score: |
0.8861 |