circRNA basic information
circBase ID: hsa_circ_0001875
Name: hsa_circ_FAM120A
Synonym: hsa_circ_104821
Host Gene: FAM120A
Genomic location(hg19): chr9:96233422-96261168:+
Genomic location(hg38): chr9:93471140-93498886:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

breast cancer lesions; adjacent normal-appearing tissues; breast cancer tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: hsa-miR-409-3p, hsa-miR-153-3p, hsa-miR-145-5p, hsa-miR-9-5p, hsa-miR-152-3p
Biological function: May promote carcinogenesis of breast cancer.
Molecular mechanism: Predicted miRNA sequestration via MREs (miRNA sponge/ceRNA-like mechanism).
Biological pathway or process:

ceRNA regulation (other)
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; divergent primers PCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_104821 (circBase: hsa_circ_0001875), derived from FAM120A, is up-regulated in breast cancer tissues and is suggested to act through predicted miRNA binding/MRE-mediated regulation.
Confidence score:

0.5963
Other information
Title:

Identification of circular RNAs as a promising new class of diagnostic biomarkers for human breast cancer.

Journal: Oncotarget
Published: 2017
PubMed ID: 28484086
Study type:

combined biological and clinical study
Data availability: -
Code availability: -