circRNA basic information
circBase ID: hsa_circ_0072309
Name: -
Synonym: circ_0072309
Host Gene: -
Genomic location(hg19): chr5:38523520-38530768:-
Genomic location(hg38): chr5:38523418-38530666:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005233
MONDO name: non-small cell lung carcinoma
Disease details: non-small cell lung cancer / NSCLC
Disease DO ID:
 3908
Disease MeSH ID:
 D002289
Disease NCIt ID:
 C2926
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

primary lung cancer tissue; normal adjacent lung tissue; brain metastasis tissue; serum; mouse brain tissue
Cell lines:

A549
In vivo animal model:

cell line-derived xenograft
circRNA-disease information
Expression pattern:
UP
Associated gene: ACKR3
Associated microRNA: miR-100
Biological function: promotes brain metastasis formation/progression in NSCLC; associated with advanced TNM stage, more BM foci, and worse OS/PFS
Molecular mechanism: Regulates the miR-100/ACKR3 signaling pathway (ceRNA-like upstream regulation inferred but not directly validated in this study).
Biological pathway or process:

metastasis (promotes); ceRNA regulation (other)
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; Cohort Study; Survival Analysis; In Vivo Animal Model; Transfection; Western Blot; ELISA; H&E Staining; Bioinformatics Analysis
Clinical significance:

Serum hsa_circ_0072309 level is associated with advanced TNM stage, more BM foci, and decreased post-operative OS and PFS; proposed as diagnostic/prognostic biomarker and therapeutic target for NSCLC-derived BM.
Description:

hsa_circ_0072309 is up-regulated in primary lung tumors, brain metastasis tissues, and serum of NSCLC patients with BM. High serum levels correlate with advanced TNM stage, more BM foci, and poorer OS/PFS, and functionally promote BM formation in a mouse model via the miR-100/ACKR3 axis.
Confidence score:

0.6806
Other information
Title:

Circulating hsa_circ_0072309, acting via the miR-100/ACKR3 pathway, maybe a potential biomarker for the diagnosis, prognosis, and treatment of brain metastasis from non-small-cell lung cancer.

Journal: Cancer medicine
Published: 2023
PubMed ID: 37496297
Study type:

combined biological and clinical study
Data availability: All data produced or analyzed in the current research are included within this paper.
Code availability: -