circRNA basic information
circBase ID: hsa_circ_0001451
Name: hsa_circ_FBXW7
Synonym: circFBXW7
Host Gene: FBXW7
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

serum
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: Associated with breast cancer diagnosis as a circulating biomarker; decreased serum expression in patients.
Molecular mechanism: not specified
Biological pathway or process:

not specified
Detected method:
Q
Validation methods:

RT-qPCR; Clinical Sample Validation; ROC Analysis
Clinical significance:

Serum circFBXW7 correlated with BC diagnosis and showed diagnostic performance by ROC analysis (PPV 87.6% at cut-off 6.17; AUC 0.655).
Description:

Serum circFBXW7 is significantly down-regulated in breast cancer patients versus healthy controls and correlates with BC diagnosis. It shows potential as a non-invasive diagnostic biomarker based on ROC analysis.
Confidence score:

0.4187
Other information
Title:

The Diagnostic Value of circFBXW7, circABCB10, and circ0103552 Levels in Breast Cancer.

Journal: Current issues in molecular biology
Published: 2024
PubMed ID: 39727990
Study type:

clinical study
Data availability: -
Code availability: -