circRNA basic information
circBase ID: hsa_circ_0001429
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr4:103610730-103612114:-
Genomic location(hg38): chr4:102689573-102690957:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007254
MONDO name: breast cancer
Disease details: breast cancer / BC
Disease DO ID:
 1612
Disease MeSH ID:
 -
Disease NCIt ID:
 C9335
Disease ICD11 ID:
 1047754165
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

-
Cell lines:

MCF-10A; BT474; SKBr-3; ZR-75-30; MCF7
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: KDM4A, AGO2
Associated microRNA: miR-205
Biological function: promotes breast cancer cell proliferation, migration, and invasion; inhibits apoptosis
Molecular mechanism: Acts as a miRNA sponge (ceRNA) by binding miR-205, thereby regulating the miR-205 target gene KDM4A; associates with AGO2 in RISC.
Biological pathway or process:

proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; RIP (RNA Immunoprecipitation); RNA Pull-Down; Luciferase Reporter Assay; Transfection; MTT; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot
Clinical significance:

-
Description:

hsa_circ_0001429 is up-regulated in breast cancer cell lines and promotes malignant phenotypes (proliferation, migration, invasion) while inhibiting apoptosis. Mechanistically, it functions as a ceRNA by binding miR-205 (with AGO2 association) to regulate the miR-205 target KDM4A.
Confidence score:

0.6306
Other information
Title:

Investigation of the Mechanism of hsa_circ_000 1429 Adsorbed miR-205 to Regulate KDM4A and Promote Breast Cancer Metastasis.

Journal: Contrast media & molecular imaging
Published: 2022
PubMed ID: 35833065
Study type:

biological research
Data availability: The data used to support the findings of this study are available from the corresponding author upon request.
Code availability: -