| Expression pattern: |
UP |
| Associated gene: |
N-cadherin |
| Associated microRNA: |
- |
| Biological function: |
Promotes TNBC cell growth, migration, invasion, and lung metastasis; knockdown inhibits migration, invasion, and metastasis. |
| Molecular mechanism: |
circ_0105487 is positively related to EMT and promotes TNBC migration and invasion by regulating and inducing N-cadherin. |
| Biological pathway or process: |
EMT (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes) |
| Detected method: |
Q
M
|
| Validation methods: |
Microarray; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); RNA-seq; Western Blot; IF (Immunofluorescence) |
| Clinical significance: |
Potential diagnostic biomarker and therapeutic target in TNBC. |
| Description: |
hsa_circ_0105487/circ_0105487 is up-regulated in TNBC tumor tissues and TNBC cell lines. It promotes TNBC cell growth, migration, invasion, and lung metastasis, at least partly through EMT-associated induction of N-cadherin. The study proposes hsa_circ_0105487 as a potential diagnostic biomarker and therapeutic target for TNBC. |
| Confidence score: |
0.6921 |