| Expression pattern: |
UP |
| Associated gene: |
NOX4 |
| Associated microRNA: |
miR-944, miR-1277, miR-7, miR-1299 |
| Biological function: |
Promotes HCC cell proliferation, migration, and invasion. |
| Molecular mechanism: |
ciRS-7 acts as a microRNA sponge for miR-944 and upregulates NOX4 expression through the miR-944/NOX4 pathway. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RNA Pull-Down; Luciferase Reporter Assay; Transfection; CCK8; MTT; Wound Healing Assay; Transwell Assay; Western Blot; Bioinformatics Analysis |
| Clinical significance: |
ciRS-7 could be a promising therapeutic target for HCC. |
| Description: |
ciRS-7 is upregulated in hepatocellular carcinoma cells and tumor tissues. It promotes HCC proliferation, migration, and invasion by acting as a sponge for miR-944, thereby increasing NOX4 expression. The study proposes ciRS-7 and the ciRS-7/miR-944/NOX4 axis as potential therapeutic targets for HCC. |
| Confidence score: |
0.7795 |