circRNA basic information
circBase ID: hsa_circ_0012586
Name: -
Synonym: circ_0012586
Host Gene: -
Genomic location(hg19): chr1:53535472-53537300:+
Genomic location(hg38): chr1:53069800-53071628:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0009807
MONDO name: osteosarcoma
Disease details: osteosarcoma / OS
Disease DO ID:
 3347
Disease MeSH ID:
 D012516
Disease NCIt ID:
 C9145
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

primary osteosarcoma tissues; lung metastatic lesions
Cell lines:

MG63; 143B; hFOB1.19; 293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: MFAP5
Associated microRNA: miR-200b-5p
Biological function: Promotes osteosarcoma cell viability, migration, and invasion; facilitates osteosarcoma lung metastasis.
Molecular mechanism: Acts as a ceRNA by sponging miR-200b-5p to regulate MFAP5.
Biological pathway or process:

ceRNA regulation (other); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis; Transfection; CCK8; Transwell Assay; Luciferase Reporter Assay; Western Blot
Clinical significance:

-
Description:

circ_0012586 is up-regulated in highly metastatic osteosarcoma cells/tissues and lung-metastatic lesions. It promotes osteosarcoma cell viability, migration, and invasion by acting as a ceRNA that sponges miR-200b-5p to increase MFAP5 expression, contributing to osteosarcoma lung metastasis.
Confidence score:

0.6777
Other information
Title:

Whole-transcriptome analysis reveals the interactions of mRNAs and ncRNAs to predict and validate ceRNA networks in osteosarcoma with lung metastases.

Journal: Journal of Cancer
Published: 2025
PubMed ID: 40959103
Study type:

combined biological and clinical study
Data availability: -
Code availability: -