circRNA basic information
circBase ID: -
Name: hsa_circ_CYP24A1
Synonym: circCYP24A1
Host Gene: CYP24A1
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: exosome
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005580
MONDO name: esophageal squamous cell carcinoma
Disease details: esophageal squamous cell carcinoma / ESCC
Disease DO ID:
 3748
Disease MeSH ID:
 C562729; D000077277
Disease NCIt ID:
 C4024
Disease ICD11 ID:
 1417891145
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

ESCC tissues; adjacent normal tissues; plasma
Cell lines:

TE-1; KYSE-150; KYSE-410; Het-1A; KYSE-510
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: promotes migration; promotes invasion; promotes epithelial-mesenchymal transition; promotes tumor metastasis
Molecular mechanism: Functional knockdown indicates circCYP24A1 promotes EMT marker changes (E-cadherin up; N-cadherin/vimentin/snail down upon knockdown); specific upstream/downstream molecular axis not defined.
Biological pathway or process:

EMT (promotes); migration (promotes); invasion (promotes); metastasis (promotes)
Detected method:
Q
H
S
Validation methods:

RNA-seq; RT-qPCR; FISH / smFISH; RNase R Treatment; Actinomycin D / DRB Stability Assay; divergent primers PCR; Sanger Sequencing; Transfection; CCK8; Wound Healing Assay; Transwell Assay; Western Blot; Clinical Sample Validation; Survival Analysis; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Upregulated in plasma and tissues and associated with lymph node metastasis and TNM stage; diagnostic biomarker for ESCC (AUC 0.94) and predictive factor for LNM (AUC 0.76); high level associated with shorter overall survival/poor prognosis.
Description:

CircCYP24A1 is significantly up-regulated in ESCC tissues and patient plasma, correlating with lymph node metastasis, advanced TNM stage, and poorer survival. Functionally, circCYP24A1 promotes ESCC cell migration, invasion, and EMT in vitro, and shows strong diagnostic performance in plasma (AUC 0.94) with predictive value for LNM (AUC 0.76).
Confidence score:

0.8283
Other information
Title:

Plasma CircCYP24A1 as a Novel Biomarker of Esophageal Squamous Cell Carcinoma.

Journal: Technology in cancer research & treatment
Published: 2024
PubMed ID: 39692561
Study type:

combined biological and clinical study
Data availability: GSE263647
Code availability: -