| Expression pattern: |
UN |
| Associated gene: |
KLF4, MYC, CCNA2, RACGAP1, CD44 |
| Associated microRNA: |
hsa-miR-150-5p |
| Biological function: |
Potentially regulates survival-related genes in CRC via a ceRNA sub-network; implicated (via prior studies discussed) in CRC progression, apoptosis, and cell proliferation. |
| Molecular mechanism: |
ceRNA/miRNA sponge mechanism (sequesters hsa-miR-150-5p) with downstream effects on hub genes (e.g., MYC, CCNA2, RACGAP1). |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (other); apoptosis (other); cell cycle (promotes); Wnt/beta-catenin (other) |
| Detected method: |
M
|
| Validation methods: |
Microarray; Bioinformatics Analysis; Survival Analysis; ROC Analysis |
| Clinical significance: |
Identified in a ceRNA sub-network with potential regulatory effect on survival-related genes; proposed as potential diagnostic/prognostic biomarker pending experimental validation. |
| Description: |
This study’s in-silico ceRNA sub-network suggests hsa_circ_0001955 may sponge hsa-miR-150-5p and thereby influence survival-related hub genes (e.g., MYC, CCNA2, RACGAP1, CD44) in colorectal cancer. The work proposes biomarker potential but provides no experimental wet-lab validation. |
| Confidence score: |
0.459 |