circRNA basic information
circBase ID: hsa_circ_0005728
Name: hsa_circ_UBE2D2
Synonym: -
Host Gene: UBE2D2
Genomic location(hg19): chr5:138979956-138994551:+
Genomic location(hg38): chr5:139600371-139614966:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0002974
MONDO name: cervical cancer
Disease details: cervical cancer / CC
Disease DO ID:
 4362
Disease MeSH ID:
 -
Disease NCIt ID:
 C9311
Disease ICD11 ID:
 1256072522
Disease OMIM ID:
 603956
Species: Human
Species details: Homo sapiens
Tissue specimen:

cervical cancer tissue; adjacent normal tissue (ANT)
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: UBE2D2
Associated microRNA: -
Biological function: -
Molecular mechanism: Predicted ceRNA network linking candidate circRNAs, target miRNAs and the mRNAs of host genes.
Biological pathway or process:

ubiquitination (other); ceRNA regulation (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; divergent primers PCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0005728 (host gene UBE2D2) is a key candidate circRNA related to the ubiquitin mediated proteolysis gene set and is validated by qRT-PCR as up-regulated in HPV-16 mediated SCC and ADC tissues versus adjacent normal tissues. It contributed to the construction of a predicted circRNA-miRNA-mRNA (ceRNA) network with host genes as downstream mRNA nodes.
Confidence score:

0.5135
Other information
Title:

Comprehensive profile and contrastive analysis of circular RNA expression in cervical squamous carcinoma and adenocarcinoma.

Journal: PeerJ
Published: 2023
PubMed ID: 36721776
Study type:

combined biological and clinical study
Data availability: NCBI’s Gene Expression Omnibus (GEO) (accession number not provided in text)
Code availability: -