| Expression pattern: |
UP |
| Associated gene: |
ZBTB20, Ago2, Bax, Bcl-2, Ki67 |
| Associated microRNA: |
miR-876-3p |
| Biological function: |
Circ_0104345 acts as an oncogenic circRNA in breast cancer; its knockdown inhibits cell proliferation, viability, migration, invasion, angiogenesis and xenograft tumor growth, and promotes apoptosis. |
| Molecular mechanism: |
Circ_0104345 functions as a miR-876-3p sponge and regulates ZBTB20 expression through miR-876-3p, forming a circ_0104345/miR-876-3p/ZBTB20 ceRNA axis in breast cancer cells. |
| Biological pathway or process: |
ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); angiogenesis (promotes); apoptosis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; RIP (RNA Immunoprecipitation); Luciferase Reporter Assay; Transfection; CCK8; EdU Staining; Wound Healing Assay; Transwell Assay; Tube Formation Assay; Annexin V/PI Flow Cytometry; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
- |
| Description: |
Circ_0104345 is up-regulated in breast cancer tissues and cells and functions as an oncogenic circRNA. Mechanistically, cytoplasmic circ_0104345 sponges miR-876-3p to regulate ZBTB20 expression, thereby promoting proliferation, migration, invasion, angiogenesis and tumor growth while suppressing apoptosis. |
| Confidence score: |
0.8175 |