| Expression pattern: |
UP |
| Associated gene: |
EGFR |
| Associated microRNA: |
miR-433 |
| Biological function: |
Promotes cervical cancer cell proliferation, migration and invasion, and inhibits apoptosis; knockdown suppresses cell viability, migratory and invasive capacities and increases apoptotic cells. |
| Molecular mechanism: |
circ-ATP8A2 acts as a ceRNA by sponging miR-433, thereby relieving miR-433-mediated suppression of EGFR expression at the post-transcriptional level. |
| Biological pathway or process: |
ceRNA regulation (promotes); EGFR (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Western Blot; Cohort Study; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circ-ATP8A2 expression is correlated with higher FIGO stage, positive lymph node invasion, myometrial invasion, and worse overall survival in cervical cancer patients. |
| Description: |
circ-ATP8A2 is up-regulated in cervical cancer tissues and cell lines and its high expression is associated with aggressive clinicopathologic features and poor overall survival. Functionally, circ-ATP8A2 promotes proliferation, migration and invasion while inhibiting apoptosis. Mechanistically, it acts as a ceRNA for miR-433 to increase EGFR expression and drive cervical cancer cell progression. |
| Confidence score: |
0.7396 |