circRNA basic information
circBase ID: hsa_circ_0002457
Name: hsa_circ_ATX2
Synonym: circATX2
Host Gene: -
Genomic location(hg19): chr12:111990083-111993723:-
Genomic location(hg38): chr12:111552279-111555919:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tumors; tumor tissues
Cell lines:

PLC/PRF/5; MHCC97H; HCCLM3
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: circATX2 was identified as a TAM-upregulated candidate circRNA in HCC cells, but elevated circATX2 levels showed no prognostic correlation and no further functional mechanism was reported.
Molecular mechanism: -
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; circRNA-seq; RT-qPCR; Clinical Sample Validation; Survival Analysis; Bioinformatics Analysis
Clinical significance:

Elevated circATX2 levels showed no correlation with overall survival or cumulative recurrence in the tested HCC cohort.
Description:

circATX2 was one of two candidate circRNAs significantly upregulated in TAM-treated HCC cells after circRNA sequencing and qRT-PCR validation. Unlike circMRCKalpha, elevated circATX2 expression did not correlate with HCC patient survival or recurrence, and the paper did not report additional functional or mechanistic studies for circATX2.
Confidence score:

0.6676
Other information
Title:

Tumor-associated macrophage-induced circMRCKalpha encodes a peptide to promote glycolysis and progression in hepatocellular carcinoma.

Journal: Cancer letters
Published: 2024
PubMed ID: 38642609
Study type:

combined biological and clinical study
Data availability: Supplementary data: https://doi.org/10.1016/j.canlet.2024.216872; all data supporting the findings are available upon reasonable request from the corresponding authors
Code availability: -