circRNA basic information
circBase ID: -
Name: hsa_circ_FCHSD2
Synonym: hsa_circ_0338
Host Gene: FCHSD2
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: extracellular vesicle
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005575
MONDO name: colorectal cancer
Disease details: colorectal cancer / CRC
Disease DO ID:
 5672, 9256
Disease MeSH ID:
 -
Disease NCIt ID:
 C4978
Disease ICD11 ID:
 -
Disease OMIM ID:
 114500
Species: Human
Species details: Homo sapiens
Tissue specimen:

formalin-fixed paraffin-embedded tissue specimens; FFPE primary CRC samples
Cell lines:

HCT-116; HCT116-R; HCT116-P
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Upregulated in FOLFOX-resistant CRC cell model and validated in FFPE CRC clinical samples; selected partly because it was present in extracellular vesicles.
Molecular mechanism: Not specified.
Biological pathway or process:

chemoresistance (promotes)
Detected method:
Q
M
Validation methods:

RNase R Treatment; Microarray; RT-qPCR; Clinical Sample Validation
Clinical significance:

Upregulated in clinical FFPE CRC samples from chemotherapy responder/nonresponder patients.
Description:

hsa circ 0338 was identified as an upregulated circRNA in chemoresistant HCT116 CRC cells and was validated by qPCR in cell line samples and FFPE CRC clinical samples. The paper did not define a mechanistic axis for hsa circ 0338, but noted that it was selected partly because it was present in extracellular vesicles.
Confidence score:

0.4773
Other information
Title:

Identification of differentially expressed circular RNAs in chemoresistant colorectal cancer.

Journal: Epigenomics
Published: 2019
PubMed ID: 31020847
Study type:

combined biological and clinical study
Data availability: GSE120985
Code availability: -