| Expression pattern: |
UP |
| Associated gene: |
NONO, ZEB1 mRNA |
| Associated microRNA: |
- |
| Biological function: |
promotes lenvatinib resistance, EMT, migration, invasion, and metastasis in HCC |
| Molecular mechanism: |
binds NONO and inhibits its ubiquitin-mediated degradation, increasing NONO stability; enhances NONO-mediated nuclear export of ZEB1 mRNA and elevates ZEB1 protein, promoting EMT and lenvatinib resistance; exosomal transfer increases recipient-cell resistance |
| Biological pathway or process: |
EMT (promotes); migration (promotes); invasion (promotes); metastasis (promotes); drug resistance (promotes); ubiquitination (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
circRNA-seq; Bioinformatics Analysis; RT-qPCR; divergent primers PCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; FISH / smFISH; RNA Pull-Down; RIP (RNA Immunoprecipitation); IF (Immunofluorescence); Co-IP; Western Blot; Transfection; CCK8; Colony Formation Assay; Wound Healing Assay; Transwell Assay; In Vivo Animal Model; H&E Staining; Survival Analysis; Clinical Sample Validation; Cohort Study |
| Clinical significance: |
High hsa_circ_0007132 expression is associated with poorer recurrence-free survival (RFS) in HCC patients. |
| Description: |
hsa_circ_0007132 is upregulated in HCC (including serum exosomes and lenvatinib-resistant settings) and promotes lenvatinib resistance and metastatic traits. It binds the RBP NONO, inhibits NONO ubiquitination/proteasomal degradation, and increases NONO-driven nuclear export of ZEB1 mRNA, elevating ZEB1 protein and EMT. Exosomal transfer of hsa_circ_0007132 can confer resistance phenotypes to recipient HCC cells. |
| Confidence score: |
0.8929 |