| Expression pattern: |
UP |
| Associated gene: |
BCAT2, TRIM21, NRF2, HO-1 |
| Associated microRNA: |
- |
| Biological function: |
promotes proliferation; promotes colony formation; promotes migration and invasion; promotes tumor growth and lung metastasis; promotes BCAA metabolism/utilization; inhibits apoptosis; increases intracellular ROS tolerance |
| Molecular mechanism: |
circ_0126925 binds BCAT2 (mitochondria) and acts as a scaffold to hinder TRIM21 recruitment to BCAT2, reducing BCAT2 ubiquitination/degradation and sustaining BCAA metabolism; activates NRF2/HO-1 antioxidant signaling to suppress apoptosis. |
| Biological pathway or process: |
mitochondrial function (other); oxidative phosphorylation (unclear); lipid metabolism (not specified); apoptosis (inhibits); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); other pathway/process (other) |
| Detected method: |
Q
H
|
| Validation methods: |
Back-Splice Junction PCR / divergent primers PCR; RNase R Treatment; Sanger Sequencing; RT-qPCR; ISH (In Situ Hybridization); FISH / smFISH; RIP (RNA Immunoprecipitation); RNA Pull-Down; Western Blot; IF (Immunofluorescence); Transfection; CCK8; Colony Formation Assay; Transwell Assay; IHC (Immunohistochemistry); In Vivo Animal Model; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
increased expression was associated with a poor overall survival rate in patients with colorectal cancer |
| Description: |
In colorectal cancer, circ_0126925 is up-regulated and promotes proliferation, invasion, tumor growth and metastasis. Mechanistically, it binds mitochondrial BCAT2 and interferes with TRIM21-mediated ubiquitination/degradation of BCAT2, sustaining BCAA metabolism and enhancing ROS tolerance via NRF2/HO-1 signaling, thereby suppressing apoptosis. High circ_0126925 expression is associated with poor overall survival. |
| Confidence score: |
0.8634 |