circRNA basic information
circBase ID: hsa_circ_0006440
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr17:13442383-13445247:-
Genomic location(hg38): chr17:13539066-13541930:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005061
MONDO name: lung adenocarcinoma
Disease details: lung adenocarcinoma
Disease DO ID:
 3910
Disease MeSH ID:
 C538231
Disease NCIt ID:
 C3512
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

lung adenocarcinoma tissue; adjacent normal tissue
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DS
Associated gene: -
Associated microRNA: -
Biological function: Identified by dataset analysis as a differentially expressed circRNA associated with osimertinib resistance in lung adenocarcinoma.
Molecular mechanism: Included in the predicted circRNA-miRNA-mRNA regulatory network associated with osimertinib resistance, but no individual validated mechanism was reported.
Biological pathway or process:

ceRNA regulation (other); drug resistance (other)
Detected method:
M
Validation methods:

Microarray; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0006440 was identified through GEO microarray dataset analysis as a differentially expressed circRNA associated with osimertinib resistance in LUAD. Its individual regulatory partners and biological functions were not experimentally validated in this paper.
Confidence score:

0.1768
Other information
Title:

Identifying circRNA-miRNA-mRNA Networks Associated with Osimertinib Resistance in Lung Adenocarcinoma by Analyzing Microarray Datasets.

Journal: Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer
Published: 2025
PubMed ID: 40493902
Study type:

bioinformatics study
Data availability: GSE146689; GSE161348; GSE263003; GSE244311; ENCORI/starBase; Circular RNA Interactome; TargetScan
Code availability: -