circRNA basic information
circBase ID: hsa_circ_0005075
Name: hsa_circ_EIF4G3
Synonym: circ_0005075
Host Gene: EIF4G3
Genomic location(hg19): chr1:21377358-21415706:-
Genomic location(hg38): chr1:21050865-21089213:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

HCC tissues; para-carcinoma tissue
Cell lines:

HepG2; SMMC-7721; Huh7; BEL-7402; LO2; 293T
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-431
Biological function: hsa_circ_0005075 promotes HCC cell proliferation, migration and invasion, and inhibits apoptosis; repression of hsa_circ_0005075 inhibits proliferation, migration and invasion and promotes apoptosis.
Molecular mechanism: hsa_circ_0005075 functions as a miRNA sponge/ceRNA that targets and inhibits miR-431, thereby promoting HCC cell proliferation, migration and invasion.
Biological pathway or process:

ceRNA regulation (promotes); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits); cell cycle (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; Sanger Sequencing; Transfection; MTT; Cell Cycle Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; Western Blot; Clinical Sample Validation; H&E Staining; Bioinformatics Analysis
Clinical significance:

hsa_circ_0005075 is highly expressed in HCC tissues and may be a potential target for HCC therapy.
Description:

hsa_circ_0005075 is up-regulated in HCC tissues and HCC cell lines. Functionally, it promotes SMMC-7721 cell proliferation, migration and invasion while suppressing apoptosis. Mechanistically, the study supports that hsa_circ_0005075 acts as a miR-431 sponge/ceRNA, and miR-431 inhibition rescues the effects of hsa_circ_0005075 knockdown.
Confidence score:

0.7181
Other information
Title:

Emerging roles of hsa_circ_0005075 targeting miR-431 in the progress of HCC.

Journal: Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
Published: 2018
PubMed ID: 29710484
Study type:

combined biological and clinical study
Data availability: Supplementary material related to this article can be found, in the online version, at doi: https://doi.org/10.1016/j.biopha.2018.01.150.
Code availability: -