| Expression pattern: |
UP |
| Associated gene: |
GRB7, Ago2 |
| Associated microRNA: |
miR-138-5p |
| Biological function: |
promotes migration and invasion; promotes metastasis and progression |
| Molecular mechanism: |
ceRNA mechanism: circDOCK1 sponges miR-138-5p to upregulate GRB7 |
| Biological pathway or process: |
migration (promotes); invasion (promotes); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Clinical Sample Validation; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; Transwell Assay; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
CircDOCK1 expression was elevated in breast cancer patients and correlated with adverse clinicopathologic parameters; patients with high circDOCK1 level had poor outcomes. |
| Description: |
circDOCK1 is up-regulated in HER2-positive breast cancer and promotes migration/invasion and metastatic progression. Mechanistically, circDOCK1 acts as a ceRNA by sponging miR-138-5p to increase GRB7 expression. High circDOCK1 expression correlates with adverse clinicopathologic features and poorer DFS/OS. |
| Confidence score: |
0.7474 |