circRNA basic information
circBase ID: hsa_circ_0031584
Name: -
Synonym: -
Host Gene: -
Genomic location(hg19): chr14:32559707-32586493:+
Genomic location(hg38): chr14:32090501-32117287:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0007256
MONDO name: hepatocellular carcinoma
Disease details: hepatocellular carcinoma / HCC
Disease DO ID:
 684, 686
Disease MeSH ID:
 D006528
Disease NCIt ID:
 C3099
Disease ICD11 ID:
 1294035808
Disease OMIM ID:
 114550
Species: Human
Species details: Homo sapiens
Tissue specimen:

tumor specimens
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: CD151
Associated microRNA: hsa-miR-214-3p
Biological function: carcinogenic potential
Molecular mechanism: ceRNA mechanism (circRNA-miRNA-mRNA network)
Biological pathway or process:

ceRNA regulation (other); angiogenesis (promotes); metastasis (promotes); invasion (promotes)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0031584 is up-regulated in TERT promoter-mutant HCC and is included in a proposed ceRNA axis hsa_circ_0031584-hsa-miR-214-3p-CD151. Through this axis, it is suggested to contribute to carcinogenic potential, potentially linked to CD151-associated angiogenesis, invasiveness, and metastasis.
Confidence score:

0.1768
Other information
Title:

Integrated Analysis of Altered lncRNA, circRNA, microRNA, and mRNA Expression in Hepatocellular Carcinoma Carrying TERT Promoter Mutations.

Journal: Journal of hepatocellular carcinoma
Published: 2022
PubMed ID: 36471741
Study type:

combined biological and clinical study
Data availability: Sequence Read Archive (SRA) PRJNA808183
Code availability: -