| Expression pattern: |
UP |
| Associated gene: |
ADAM10, Ago2 |
| Associated microRNA: |
miR-1294 |
| Biological function: |
promotes ESCC cell proliferation, migration, invasion, angiogenesis, stem-like properties, and tumor growth |
| Molecular mechanism: |
circ_0096710 acts as a miRNA sponge for miR-1294 to upregulate ADAM10 |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); angiogenesis (promotes); stemness (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; RNase R Treatment; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; ROC Analysis; Survival Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Transwell Assay; Tube Formation Assay; Western Blot; IHC (Immunohistochemistry); In Vivo Animal Model |
| Clinical significance: |
circ_0096710 could effectively distinguish ESCC from normal tissues; high circ_0096710 expression showed poor survival |
| Description: |
circ_0096710 is upregulated in ESCC and promotes malignant phenotypes and xenograft tumor growth. Mechanistically, it acts as a cytoplasmic ceRNA that sponges miR-1294 to increase ADAM10 expression, and high circ_0096710 is associated with worse patient survival and diagnostic potential. |
| Confidence score: |
0.8449 |