| Expression pattern: |
UP |
| Associated gene: |
CCL25, MAP2K1 |
| Associated microRNA: |
- |
| Biological function: |
promotes invasion and migration of HCC cells; promotes xenograft tumor growth in vivo |
| Molecular mechanism: |
positively regulates CCL25 (and MAP2K1) expression; implicated in a circRNA-related ceRNA network |
| Biological pathway or process: |
migration (promotes); invasion (promotes); metastasis (promotes); angiogenesis (promotes); ceRNA regulation (other); MAPK (other); ERK (other) |
| Detected method: |
Q
S
M
|
| Validation methods: |
circRNA-seq; Microarray; RT-qPCR; Clinical Sample Validation; Transfection; Transwell Assay; Wound Healing Assay; Western Blot; In Vivo Animal Model; Bioinformatics Analysis |
| Clinical significance: |
circ_0000069 was significantly upregulated in HCC tissues compared to adjacent controls, suggesting potential as a therapeutic target |
| Description: |
circ_0000069 (hsa_circ_0000069) is upregulated in hepatocellular carcinoma tissues and cell lines and promotes HCC cell migration/invasion. Its pro-tumor effects in vitro and xenograft growth in vivo are linked to positive regulation of CCL25 (and associated changes in MAP2K1/MEK1 protein levels). |
| Confidence score: |
0.6815 |