| Expression pattern: |
DN |
| Associated gene: |
FOXO3, Ago2 |
| Associated microRNA: |
miR-376c-3p |
| Biological function: |
CircEXOC6B suppresses ovarian cancer cell proliferation, migration, invasion, metastasis, and paclitaxel resistance, and promotes paclitaxel-induced apoptosis. |
| Molecular mechanism: |
CircEXOC6B acts as a miR-376c-3p decoy/sponger to upregulate FOXO3, thereby suppressing ovarian cancer progression and paclitaxel resistance. |
| Biological pathway or process: |
proliferation (inhibits); migration (inhibits); invasion (inhibits); metastasis (inhibits); apoptosis (promotes); chemoresistance (inhibits); drug resistance (inhibits); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Transfection; CCK8; Colony Formation Assay; Transwell Assay; Western Blot; Annexin V/PI Flow Cytometry; In Vivo Animal Model; Survival Analysis; Cohort Study |
| Clinical significance: |
Low circEXOC6B level is associated with malignant pathological characteristics and poor prognosis, while high circEXOC6B expression is associated with longer survival time in ovarian cancer patients; circEXOC6B might be a promising prognostic marker. |
| Description: |
CircEXOC6B is down-regulated in ovarian cancer tissues and cells, and low expression is associated with malignant clinicopathological features and shorter survival. Functionally, circEXOC6B inhibits ovarian cancer cell proliferation, migration, invasion, and paclitaxel resistance while enhancing paclitaxel sensitivity. Mechanistically, circEXOC6B mainly localizes in the cytoplasm and acts through the miR-376c-3p/FOXO3 axis. |
| Confidence score: |
0.798 |