| Expression pattern: |
UP |
| Associated gene: |
GFRA1, Ago2 |
| Associated microRNA: |
miR-449a |
| Biological function: |
promotes cell proliferation and invasion; inhibits apoptosis; promotes tumor growth and metastasis in vivo |
| Molecular mechanism: |
ceRNA/miRNA sponge: circGFRA1 sponges miR-449a to regulate GFRA1 |
| Biological pathway or process: |
proliferation (promotes); invasion (promotes); apoptosis (inhibits); metastasis (promotes); ceRNA regulation (promotes) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Nuclear-Cytoplasmic Fractionation; Clinical Sample Validation; Transfection; CCK8; Annexin V/PI Flow Cytometry; Transwell Assay; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); Western Blot; In Vivo Animal Model; H&E Staining |
| Clinical significance: |
circGFRA1 could be a potential diagnostic biomarker and therapeutic target for ovarian cancer. |
| Description: |
circGFRA1 is up-regulated in ovarian cancer tissues and promotes malignant phenotypes (proliferation, invasion, and in vivo tumor growth/metastasis) while inhibiting apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-449a to increase GFRA1 expression. |
| Confidence score: |
0.7099 |