| Expression pattern: |
UP |
| Associated gene: |
Ago2, CyclinD1, E-cad, N-cad, Cleaved-caspase-3, Cleaved-caspase-9 |
| Associated microRNA: |
miR-194, miR-204 |
| Biological function: |
Circ_0001971 promotes OSCC cell proliferation, migration, invasion, EMT, tumorigenesis, progression and DDP resistance, while inhibiting apoptosis; circ_0001971 knockdown enhances DDP sensitivity and induces apoptosis. |
| Molecular mechanism: |
Circ_0001971 acts as a cytoplasmic ceRNA by directly targeting miR-194 and miR-204; inhibition of miR-194 or miR-204 reverses the effects of circ_0001971 knockdown in OSCC cells. |
| Biological pathway or process: |
proliferation (promotes); migration (promotes); invasion (promotes); EMT (promotes); apoptosis (inhibits); drug resistance (promotes); chemoresistance (promotes); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; Transfection; CCK8; Transwell Assay; Annexin V/PI Flow Cytometry; Western Blot; Actinomycin D / DRB Stability Assay; Nuclear-Cytoplasmic Fractionation; Bioinformatics Analysis; Luciferase Reporter Assay; RIP (RNA Immunoprecipitation); In Vivo Animal Model; Survival Analysis |
| Clinical significance: |
High circ_0001971 expression is associated with advanced TNM stage and poor prognosis in OSCC patients; circ_0001971 is proposed as a promising therapeutic target for OSCC. |
| Description: |
Circ_0001971 is up-regulated in OSCC tissues and cell lines and is associated with advanced TNM stage and poorer overall survival. Functionally, circ_0001971 promotes malignant phenotypes and DDP resistance while suppressing apoptosis, and its knockdown inhibits tumor progression and improves DDP sensitivity in vitro and in vivo. Mechanistically, circ_0001971 acts mainly in the cytoplasm and directly targets miR-194 and miR-204. |
| Confidence score: |
0.817 |