| Expression pattern: |
DN |
| Associated gene: |
AKAP12 |
| Associated microRNA: |
miR-95-3p |
| Biological function: |
circ_0001777 suppresses TNBC cell proliferation, migration, invasion, EMT-related protein expression and tumor growth, and promotes apoptosis. |
| Molecular mechanism: |
circ_0001777 acts as a ceRNA sponge for miR-95-3p to positively regulate AKAP12 expression, thereby inhibiting TNBC progression. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (inhibits); migration (inhibits); invasion (inhibits); apoptosis (promotes); EMT (inhibits); metastasis (inhibits) |
| Detected method: |
Q
|
| Validation methods: |
RNase R Treatment; RT-qPCR; FISH / smFISH; Clinical Sample Validation; RNA Pull-Down; Luciferase Reporter Assay; Bioinformatics Analysis; Transfection; EdU Staining; Colony Formation Assay; Annexin V/PI Flow Cytometry; Wound Healing Assay; Transwell Assay; Western Blot; In Vivo Animal Model; IHC (Immunohistochemistry); Cohort Study; Survival Analysis |
| Clinical significance: |
circ_0001777 was lower in advanced stage and metastatic TNBC, and higher circ_0001777 level was positively associated with overall survival rate. |
| Description: |
circ_0001777 is down-regulated in TNBC tissues and cell lines and mainly localized in the cytoplasm. It functions as a tumor suppressor by sponging miR-95-3p to upregulate AKAP12, thereby inhibiting proliferation, migration, invasion, EMT-related changes and xenograft tumor growth while promoting apoptosis. Higher circ_0001777 expression is associated with better overall survival in TNBC patients. |
| Confidence score: |
0.8428 |