circRNA basic information
circBase ID: hsa_circ_0002999
Name: hsa_circ_BARD1
Synonym: circBARD1
Host Gene: BARD1
Genomic location(hg19): chr2:215617170-215661841:-
Genomic location(hg38): chr2:214752446-214797117:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005076
MONDO name: periodontitis
Disease details: periodontitis
Disease DO ID:
 824, 9893
Disease MeSH ID:
 D010518
Disease NCIt ID:
 C34918
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

gingival tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: -
Biological function: Potential biomarker for periodontitis diagnosis; expression positively correlates with probing depth (PD).
Molecular mechanism: Predicted circRNA-miRNA-mRNA regulatory network (ceRNA) (bioinformatics prediction; not experimentally validated).
Biological pathway or process:

immune regulation (other); apoptosis (other); migration (other); adhesion (other); inflammation (other); ceRNA regulation (other); other pathway/process (other)
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; divergent primers PCR; Clinical Sample Validation; ROC Analysis; Bioinformatics Analysis
Clinical significance:

Higher expression correlates positively with probing depth (PD) and shows potential diagnostic value in periodontitis (ROC AUC=0.8013).
Description:

circBARD1 is significantly up-regulated in periodontitis gingival tissues and is positively associated with probing depth. It also shows potential diagnostic value (ROC AUC 0.8013) and is included in a predicted circRNA-miRNA-mRNA network, but no specific downstream miRNA/mRNA targets were experimentally validated in this study.
Confidence score:

0.5963
Other information
Title:

Identification of potentially functional circRNAs and prediction of circRNA-miRNA-mRNA regulatory network in periodontitis: Bridging the gap between bioinformatics and clinical needs.

Journal: Journal of periodontal research
Published: 2022
PubMed ID: 35388494
Study type:

combined biological and clinical study
Data availability: The data that support the findings of this study are available from the corresponding author upon reasonable request.
Code availability: -