circRNA basic information
circBase ID: hsa_circ_0005660
Name: hsa_circ_NFIX
Synonym: NFIX circular RNA
Host Gene: NFIX
Genomic location(hg19): chr19:13135834-13136366:+
Genomic location(hg38): chr19:13025020-13025552:+
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0021042
MONDO name: glioma
Disease details: glioma
Disease DO ID:
 -
Disease MeSH ID:
 D005910
Disease NCIt ID:
 C3059
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-34a-5p
Biological function: associated with proliferation of glioma cells
Molecular mechanism: miR-34a-5p regulation (miRNA-related mechanism mentioned); biosensor-based label-free detection in plasma
Biological pathway or process:

proliferation (promotes); ceRNA regulation (other)
Detected method:
Others
Validation methods:

Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

elevated circNFIX level in plasma/blood of glioma patient(s) compared with control; proposed for early revelation of cancer in humans
Description:

This study uses SOI nanoribbon biosensor chips to detect human circNFIX (hsa_circ_0005660) in plasma and reports higher circNFIX levels in glioma patient plasma than in control samples, supporting its potential as a liquid-biopsy biomarker for early glioma detection. The paper also notes a reported association of circNFIX with glioma cell proliferation via miR-34a-5p.
Confidence score:

0.2629
Other information
Title:

Nanoribbon-Based Electronic Detection of a Glioma-Associated Circular miRNA.

Journal: Biosensors
Published: 2021
PubMed ID: 34356707
Study type:

combined biological and clinical study
Data availability: -
Code availability: -