circRNA basic information
circBase ID: -
Name: mmu_circ_HIPK3
Synonym: circRNA HIPK3 / circHIPK3
Host Gene: HIPK3
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005283
MONDO name: retinal disorder
Disease details: epithelial-mesenchymal transition of retinal pigment epithelial cells
Disease DO ID:
 5679
Disease MeSH ID:
 D012164
Disease NCIt ID:
 C26875; C62601
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Mouse
Species details: Mus musculus
Tissue specimen:

-
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
UP
Associated gene: -
Associated microRNA: miR-124-3p, miR-302d-3p, miR-93-5p, miR-20a-5p, miR-20b-5p, miR-17-5p, miR-519d-3p, miR-106a-5p, miR-106b-5p, miR-222-3p
Biological function: promotes epithelial-mesenchymal transition; promotes cell migration
Molecular mechanism: ceRNA mechanism by sponging multiple miRNAs
Biological pathway or process:

EMT (promotes); migration (promotes); ceRNA regulation (promotes)
Detected method:
Q
Validation methods:

RT-qPCR; FISH / smFISH; Transfection; Luciferase Reporter Assay; RNA Pull-Down; Western Blot; IF (Immunofluorescence); Transwell Assay; Bioinformatics Analysis
Clinical significance:

Targeting circHIPK3 might serve as a therapeutic strategy in RPE-EMT associated vitreoretinal diseases.
Description:

circHIPK3 is up-regulated in a TGF-beta1-induced RPE-EMT in vitro model and promotes EMT and cell migration. It functions mainly in the cytoplasm by sponging multiple miRNAs (notably including miR-106b-5p), supporting a ceRNA-like mechanism to modulate RPE-EMT.
Confidence score:

0.6528
Other information
Title:

Circular RNA HIPK3 mediates epithelial-mesenchymal transition of retinal pigment epithelial cells by sponging multiple microRNAs.

Journal: Scientific reports
Published: 2024
PubMed ID: 39572643
Study type:

biological research
Data availability: The online version contains supplementary material available at 10.1038/s41598-024-71119-6; The data used and/or analyzed during the current study available from the corresponding author on reasonable request.
Code availability: -