| Expression pattern: |
DN |
| Associated gene: |
downstream targets, target genes, MYC |
| Associated microRNA: |
hsa-miR-141-5p, hsa-miR-589-3p |
| Biological function: |
hsa_circ_0000419 is decreased in gastric cancer and is proposed as a biomarker for GC screening and prognostic estimation; bioinformatics analysis suggests involvement in gastric tumorigenesis and progression via interactions with microRNAs. |
| Molecular mechanism: |
Predicted ceRNA-like interaction with hsa-miR-141-5p and hsa-miR-589-3p via miRNA response elements to regulate downstream target genes and cancer-related pathways. |
| Biological pathway or process: |
ceRNA regulation (other); cell cycle (other); other pathway/process (other) |
| Detected method: |
Q
M
|
| Validation methods: |
RT-qPCR; Microarray; Sanger Sequencing; Clinical Sample Validation; ROC Analysis; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
hsa_circ_0000419 is a novel biomarker for GC screening and an important indicator for prognostic estimation; lower tissue levels are associated with worse overall survival and disease-free survival, and plasma levels correlate with tumor stage, metastasis, venous invasion and perineural invasion. |
| Description: |
hsa_circ_0000419 is significantly down-regulated in gastric cancer cell lines, tumor tissues, and plasma. Its lower expression is associated with worse survival and advanced clinicopathological features, supporting its value as a GC screening and prognostic biomarker. Bioinformatics analysis suggests that it may participate in gastric tumorigenesis and progression through hsa-miR-141-5p and hsa-miR-589-3p-related downstream regulatory networks. |
| Confidence score: |
0.636 |