| Expression pattern: |
DN |
| Associated gene: |
- |
| Associated microRNA: |
- |
| Biological function: |
potential biomarker; associated with PD genetic background in sensitivity analyses |
| Molecular mechanism: |
in-silico predicted miRNA binding; circRNA-miRNA correlation; pathway enrichment via miRNAs |
| Biological pathway or process: |
Hippo/YAP (other); other pathway/process (other) |
| Detected method: |
S
|
| Validation methods: |
RNA-seq; Bioinformatics Analysis; ROC Analysis |
| Clinical significance: |
part of circRNA diagnostic models for PD and at-risk individuals |
| Description: |
circSUZ12 is down-regulated in PD blood and is highlighted as associated with genetic background, particularly in LRRK2 mutation carriers compared with SNCA carriers. It is included among high-confidence circRNAs used for miRNA-based functional enrichment and for diagnostic modeling in PD/at-risk participants. |
| Confidence score: |
0.348 |