| Expression pattern: |
UP |
| Associated gene: |
UPDRS-III, PD medication |
| Associated microRNA: |
- |
| Biological function: |
potential biomarker; associated with symptom severity and medication status; longitudinal change differs between PD and controls |
| Molecular mechanism: |
in-silico predicted miRNA binding; circRNA-miRNA correlation; pathway enrichment via miRNAs |
| Biological pathway or process: |
Hippo/YAP (other); other pathway/process (other) |
| Detected method: |
S
|
| Validation methods: |
RNA-seq; Bioinformatics Analysis; ROC Analysis |
| Clinical significance: |
part of circRNA diagnostic models for PD and at-risk individuals; potential to monitor drug response |
| Description: |
circITGAX is up-regulated in PD blood and is associated with medication status; it correlates with motor symptom severity (UPDRS-III) and shows PD-associated longitudinal trajectory differences, supporting biomarker potential for monitoring. |
| Confidence score: |
0.348 |