| Expression pattern: |
UP |
| Associated gene: |
- |
| Associated microRNA: |
miR-125b-5p |
| Biological function: |
cir-GLI2 acts as an oncogenic circRNA in osteosarcoma; it promotes OS cell proliferation, migration, and invasion and suppresses apoptosis. |
| Molecular mechanism: |
cir-GLI2 functions as a ceRNA/miRNA sponge and exerts oncogenic effects by negatively targeting miR-125b-5p. |
| Biological pathway or process: |
ceRNA regulation (other); proliferation (promotes); migration (promotes); invasion (promotes); apoptosis (inhibits) |
| Detected method: |
Q
S
M
|
| Validation methods: |
RNase R Treatment; RT-qPCR; Microarray; RNA-seq; Clinical Sample Validation; Luciferase Reporter Assay; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Transwell Assay; Bioinformatics Analysis |
| Clinical significance: |
cir-GLI2 may provide a novel diagnostic and therapeutic target for osteosarcoma. |
| Description: |
cir-GLI2/hsa_circ_0056288 is upregulated in osteosarcoma tissues and cell lines and functions as an oncogenic circRNA. Mechanistically, it acts as a ceRNA/miRNA sponge that negatively targets miR-125b-5p, thereby promoting proliferation, migration, and invasion while inhibiting apoptosis in OS cells. The study suggests cir-GLI2 may be a diagnostic and therapeutic target for osteosarcoma. |
| Confidence score: |
0.7519 |