circRNA basic information
circBase ID: hsa_circ_0009043
Name: hsa_circ_EXOC6B
Synonym: circ_0009043
Host Gene: EXOC6B
Genomic location(hg19): chr2:72945231-72960247:-
Genomic location(hg38): chr2:72718102-72733118:-
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005494
MONDO name: triple-negative breast carcinoma
Disease details: triple-negative breast cancer / TNBC
Disease DO ID:
 0060081
Disease MeSH ID:
 D064726
Disease NCIt ID:
 C71732
Disease ICD11 ID:
 -
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

adjacent frozen tissues; frozen tissues
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: AGO1, AGO2, EIF4A3, ELAVL1 (HuR), PTBP1
Associated microRNA: -
Biological function: Putatively participates in TNBC-related gene regulation via predicted RBP binding (in silico).
Molecular mechanism: Predicted circRNA-RBP interaction (CircInteractome/CLIP-seq-based).
Biological pathway or process:

not specified
Detected method:
Q
S
Validation methods:

RNA-seq; RT-qPCR; Clinical Sample Validation; Bioinformatics Analysis
Clinical significance:

-
Description:

hsa_circ_0009043 is down-regulated in TNBC in RNA-seq and was differentially expressed in frozen-tissue RT-qPCR validation; it was also analyzed via predicted circRNA-RBP interactions.
Confidence score:

0.4032
Other information
Title:

Triple-Negative Breast Cancer circRNAome Reveals Hsa_circ_0072309 as a Potential Risk Biomarker.

Journal: Cancers
Published: 2022
PubMed ID: 35805051
Study type:

combined biological and clinical study
Data availability: PRJNA808398
Code availability: -