circRNA basic information
circBase ID: -
Name: hsa_circ_ETFA
Synonym: circETFA
Host Gene: ETFA
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: not tested
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0005180
MONDO name: Parkinson disease
Disease details: Parkinson’s disease / PD
Disease DO ID:
 14330
Disease MeSH ID:
 D010300
Disease NCIt ID:
 C26845
Disease ICD11 ID:
 296066191
Disease OMIM ID:
 -
Species: Human
Species details: Homo sapiens
Tissue specimen:

blood
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: -
Associated microRNA: -
Biological function: potential biomarker
Molecular mechanism: in-silico predicted miRNA binding; circRNA-miRNA correlation; pathway enrichment via miRNAs
Biological pathway or process:

Hippo/YAP (other); other pathway/process (other)
Detected method:
S
Validation methods:

RNA-seq; Bioinformatics Analysis; ROC Analysis
Clinical significance:

part of a circRNA set used to distinguish PD and at-risk participants from healthy controls
Description:

circETFA is down-regulated in PD blood versus controls and shows evidence of association primarily in idiopathic PD rather than mutation carriers, within the study’s sensitivity analyses.
Confidence score:

0.348
Other information
Title:

Circulating blood circular RNA in Parkinson's Disease; from involvement in pathology to diagnostic tools in at-risk individuals.

Journal: NPJ Parkinson's disease
Published: 2024
PubMed ID: 39557914
Study type:

bioinformatics study
Data availability: AMP-PD (https://amp-pd.org/); pdbloodtranscriptomics.wustl.edu
Code availability: https://github.com/Ibanez-Lab/BloodCircularRNA-ParkinsonsDisease