| Expression pattern: |
UP |
| Associated gene: |
C1QBP, beta-catenin, ZNF24, UBAP2L, CBX8, MARCKSL1, CDKN2AIP, TOX3, ATP5B |
| Associated microRNA: |
- |
| Biological function: |
promotes proliferation; promotes migration; promotes invasion; promotes tumor growth and metastasis |
| Molecular mechanism: |
circMTCL1 directly binds C1QBP and inhibits its ubiquitin-proteasome-mediated degradation, increasing C1QBP protein levels; this enhances C1QBP-beta-catenin interaction, suppresses beta-catenin phosphorylation, and promotes beta-catenin accumulation/activation, activating Wnt/beta-catenin signaling. |
| Biological pathway or process: |
Wnt/beta-catenin (promotes); proliferation (promotes); migration (promotes); invasion (promotes); metastasis (promotes); ubiquitination (inhibits) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; RNase R Treatment; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; FISH / smFISH; Nuclear-Cytoplasmic Fractionation; ISH (In Situ Hybridization); RIP (RNA Immunoprecipitation); RNA Pull-Down; Co-IP; Western Blot; Transfection; EdU Staining; Transwell Assay; Wound Healing Assay; Colony Formation Assay; In Vivo Animal Model; H&E Staining; IHC (Immunohistochemistry); ROC Analysis; Survival Analysis; Bioinformatics Analysis |
| Clinical significance: |
High circMTCL1 expression predicts worse clinical outcome and worse overall survival; potential diagnostic value (ROC AUC 0.799). |
| Description: |
circMTCL1 is up-regulated in LSCC and associated with worse overall survival. It promotes LSCC proliferation, migration/invasion and in vivo tumor growth/metastasis by directly binding C1QBP to inhibit its ubiquitin-proteasome degradation, thereby enhancing beta-catenin activation and Wnt/beta-catenin signaling. |
| Confidence score: |
0.89 |