circRNA basic information
circBase ID: hsa_circ_0130810
Name: hsa_circ_KIAA1244
Synonym: -
Host Gene: KIAA1244
Genomic location(hg19): -
Genomic location(hg38): -
Subcellular localization: cytoplasm
 
 
 
 
 
 
 
Disease basic information
MONDO ID:
 0001056
MONDO name: gastric cancer
Disease details: gastric cancer
Disease DO ID:
 10534
Disease MeSH ID:
 -
Disease NCIt ID:
 C9331
Disease ICD11 ID:
 1397617262
Disease OMIM ID:
 613659
Species: Human
Species details: Homo sapiens
Tissue specimen:

plasma; gastric cancer tissues; adjacent non-tumor tissues; plasma exosomes
Cell lines:

-
In vivo animal model:

-
circRNA-disease information
Expression pattern:
DN
Associated gene: AGO2
Associated microRNA: -
Biological function: -
Molecular mechanism: Potential miRNA-binding (predicted) and association with AGO2 (RIP enrichment).
Biological pathway or process:

not specified
Detected method:
Q
M
Validation methods:

Microarray; RT-qPCR; Sanger Sequencing; RNase R Treatment; Actinomycin D / DRB Stability Assay; FISH / smFISH; RIP (RNA Immunoprecipitation); Clinical Sample Validation; ROC Analysis; Survival Analysis; Bioinformatics Analysis
Clinical significance:

Decreased plasma circ-KIAA1244 was negatively correlated with TNM stage and lymphatic metastasis; AUC=0.7481 for distinguishing GC plasmas vs normal; lower expression associated with reduced overall survival time and was an independent prognostic indicator.
Description:

circ-KIAA1244 (hsa_circ_0130810) is down-regulated in gastric cancer tissues, plasma, and GC cells. Its decreased plasma level correlates with advanced TNM stage/lymphatic metastasis, shows diagnostic value (ROC AUC ~0.75), and lower expression is associated with shorter overall survival; it is detectable in plasma exosomes and mainly localizes to the cytoplasm.
Confidence score:

0.7781
Other information
Title:

CircRNA microarray profiling identifies a novel circulating biomarker for detection of gastric cancer.

Journal: Molecular cancer
Published: 2018
PubMed ID: 30236115
Study type:

combined biological and clinical study
Data availability: Additional file 1: Figure S1a-e; Additional file 2: Figure S2a-e; Additional file 3: Figure S3a-c; Additional file 4: Figure S4; Additional file 5: Table S1; Additional file 5: Table S2
Code availability: -