| Expression pattern: |
UP |
| Associated gene: |
NR4A2 |
| Associated microRNA: |
miR-145 |
| Biological function: |
Promotes gastric cancer cell viability/proliferation, decreases apoptosis, and affects cell cycle progression; knockdown decreases proliferation and promotes apoptosis. |
| Molecular mechanism: |
circRNA_001569 acts as a ceRNA/sponge for miR-145, suppressing miR-145 and thereby regulating NR4A2-mediated proliferation and apoptosis in gastric cancer. |
| Biological pathway or process: |
proliferation (promotes); apoptosis (inhibits); cell cycle (other); ceRNA regulation (other) |
| Detected method: |
Q
|
| Validation methods: |
RT-qPCR; Clinical Sample Validation; RNA Pull-Down; Transfection; CCK8; Colony Formation Assay; Annexin V/PI Flow Cytometry; Cell Cycle Assay; Luciferase Reporter Assay; Western Blot; In Vivo Animal Model |
| Clinical significance: |
circRNA_001569 expression correlated with tumor size, clinical stage and depth of invasion; the study suggested potential value for gastric cancer diagnosis and therapy. |
| Description: |
circRNA_001569 is up-regulated in gastric cancer tissues and cell lines. It promotes gastric cancer cell proliferation/viability and inhibits apoptosis by acting as a ceRNA that absorbs miR-145, leading to regulation of NR4A2. Its expression is associated with tumor size, clinical stage and depth of invasion. |
| Confidence score: |
0.6831 |