| Expression pattern: |
DN |
| Associated gene: |
OSR1, TGF-beta signaling pathway |
| Associated microRNA: |
- |
| Biological function: |
Inhibits breast cancer cell migration and invasion; suppresses EMT progression. |
| Molecular mechanism: |
May regulate EMT via OSR1/TGF-beta axis based on circRNA-miRNA-mRNA network predictions. |
| Biological pathway or process: |
migration (inhibits); invasion (inhibits); EMT (inhibits); ceRNA regulation (other); TGF-beta/SMAD (other) |
| Detected method: |
Q
S
|
| Validation methods: |
RNA-seq; RT-qPCR; Back-Splice Junction PCR / divergent primers PCR; Sanger Sequencing; Clinical Sample Validation; Transfection; Transwell Assay |
| Clinical significance: |
May serve as biomarkers during tumor metastasis. |
| Description: |
circSCYL2 (from SCYL2 exon 2-4) is down-regulated in breast cancer tissues/cell lines and its overexpression suppresses EMT-associated migration and invasion in MCF-7 and MDA-MB-231 cells. Mechanistically, the study’s network analysis suggests circSCYL2 may influence EMT via an OSR1/TGF-beta signaling axis, but the interactions were stated to require further experimental validation. |
| Confidence score: |
0.673 |